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Irritable bowel syndrome (IBS), also known as "spastic colon," is a common disorder. While most people experience digestive troubles once in a while, what sets IBS apart is belly pain and diarrhea or constipation that comes back again and again. IBS affects 10% to 15% of people in North America.
The main symptoms of IBS are abdominal pain accompanied by a change in bowel habits. This can include constipation, diarrhea, or both. Gas and a visibly bloated belly are also common. The condition does not damage the digestive system, but persistent pain and frequent trips to the bathroom can interfere with everyday life.
Doctors don't know the exact cause of IBS. One theory is that the signals between the brain and intestines are somehow disrupted. This miscommunication may cause abnormal intestinal muscle contractions (seen on the right) that result in cramping, pain, and fluctuations in the speed of digestion. Patients have no sign of inflamed or damaged tissue or structural abnormalities in the digestive tract.
Anyone can get IBS, but the condition is twice as common in women as in men. It's also more likely to affect people who have a family history of IBS. Symptoms usually begin when people are in their late 20s. It's uncommon for people over 50 to develop IBS for the first time. IBS sometimes co-exists with depression or anxiety.
There is no standard test to check for IBS. Doctors usually make a diagnosis based on a patient's description of the symptoms. For this reason, it's important to be candid and specific about the problems you are having. Your doctor may order tests to rule out other causes of your symptoms.
IBS may not put your life at risk, but it can take a significant toll on your lifestyle. During episodes of frequent, urgent diarrhea, you may find it difficult to commute to work or travel by air. You may find it necessary to map out bathrooms before going anyplace new. In severe cases, patients may become hesitant to eat out, see a movie, or socialize.
Whether you have IBS or not, you're probably familiar with the "butterflies in the stomach" that accompany public speaking, a college final, or other high-stakes events. Stress may trigger or worsen symptoms of IBS. This means that stress can be particularly problematic for people with IBS. IBS symptoms can cause stress, and stress can make the symptoms worse, leading to a vicious cycle.
The first step toward managing IBS is to identify what makes your symptoms worse. Besides stress, common triggers include eating a meal, hormonal changes, and certain medications. It's important to note that no specific foods have been universally linked to IBS symptoms. But keeping a food diary may help you pinpoint which foods are a problem for you.
Your treatment strategy will depend on your specific symptoms and triggers, but many people start with diet changes. You may find it helpful to avoid caffeine, alcohol, and fatty foods. Getting more fiber or water may also improve symptoms. Suspicious foods can be eliminated one at a time. It may take some trial and error to discover which changes provide the most relief.
Probiotics are friendly bacteria that help reduce the growth of harmful organisms in the digestive tract. There are many kinds of probiotics, but the best known is the type found in yogurt -- look for a label that says "active cultures." Some studies suggest probiotics may reduce the occurrence of diarrhea, but more research is needed to determine whether this includes symptoms caused by IBS.
If diet changes do not provide enough relief, your doctor may recommend prescription or over-the-counter medications that target your specific symptoms. For diarrhea, the options include common antidiarrheals (such as Imodium or Lomotil), which slow the motion in the intestines. This type of medicine can also cause constipation, so keeping in close contact with your doctor is important.
Occasionally, your doctor may prescribe medication to boost the amount of fluid in the intestines. You can also ask your doctor about over-the-counter laxatives, such as Milk of Magnesia or Miralax, which make the stool softer and easier to pass. Stimulant laxatives such as Correctol and Senokot speed up the motion of stool through the intestines, but should not be used regularly.
If a doctor prescribes antidepressants for IBS, this does not suggest your symptoms are "all in your head" or caused by depression. Antidepressants act on the chemical messengers in the digestive tract and can ward off pain and cramping. Antispasmodics may also be useful if cramping is a major symptom. Most medications have side effects, so be sure to discuss the pros and cons with your doctor.
If you prefer a natural remedy, peppermint oil is worth a try. Studies suggest that it may be effective in relieving IBS symptoms. In fact, it performed better than a placebo at relieving symptoms in some people with IBS. Look for enteric-coated capsules, which are less likely to cause heartburn -- and check with your doctor first if you're taking other medications.
Because stress is known to make IBS worse, stress management can be highly beneficial. Cognitive-behavioral therapy is a form of psychotherapy that helps you replace negative thoughts with more positive or realistic ones. This can reduce stress, which in turn, reduces the pain and digestive symptoms associated with IBS. Therapy can also help you learn coping strategies for when your symptoms do flare up.
Hypnosis takes patients into an altered state of consciousness, where they receive suggestions for making the pain fade away. Some research indicates hypnosis can reduce pain, digestive symptoms, and anxiety linked to IBS.
Biofeedback teaches patients to recognize and change their body's response to stress. After a few sessions, many people are able to slow down their heart rate and enter a more relaxed state. This can be useful in relieving both the stress and symptoms of IBS.
Many people can learn to calm themselves through meditation, guided imagery, deep breathing, or other relaxation therapies. Studies suggest these techniques can help with a variety of IBS symptoms, including pain, diarrhea, and constipation. With practice, it's possible to use relaxation techniques just about anywhere.
People with IBS may not feel like exercising, especially when symptoms flare up. But physical activity can help digestion, reduce stress, and induce an overall feeling of well-being. Opt for low-impact activities at first that won't jar the digestive tract, and use the bathroom before you start. Be sure to discuss your plans with your doctor first.
IBS is a chronic condition, and patients may experience quieter periods followed by flare-ups. Keeping a personal diary of food, feelings, and symptoms can help uncover hidden triggers when people are first diagnosed -- and if IBS begins to interfere with daily life again. Over time, the symptoms of IBS typically do not get worse. IBS is not life-threatening and does not lead to more serious conditions, such as inflammatory bowel disease or cancer.
Legionnaires disease (LD) was recognized in 1976 after an outbreak of pneumoniaat an American Legion convention in Philadelphia. Soon after, the etiologic agent was identified as a fastidious gram-negative bacillus and named Legionella pneumophila. Although several other species of the genus Legionella were subsequently identified, L pneumophila is the most frequent cause of human legionellosis and a relatively common cause of community-acquired and nosocomial pneumonia in adults. In children, L pneumophila is also an important, although relatively uncommon, cause of pneumonia.
Legionellosis refers to 2 distinct clinical syndromes: Legionnaires disease, which most often manifests as severe pneumonia accompanied by multisystemic disease,and Pontiac fever, which is an acute, febrile, self-limited, viral-like illness.


معیار های تشخیصی :
حداقل دو معیار از موارد زیر :
1- سردرد یک طرفه 2- سردرد ضربان دار 3-تشدید سردرد با حرکت 4-سردرد متوسط یا شدید
به علاوه یک از معیار های زیر :
1- تهوع و استفراغ 2- ترس از نور و صدا
سابقه خانوادگی اغلب مثبت است . سه گانه کلاسیک میگرن عبارتند از : علایم پیش در امد بینایی ، حسی یا حرکتی - سردرد کوبنده یک طرفه - تهوع و استفراغ
یک حمله 4 الی 72 ساعت طول می کشد . حملات گاهی با شراب - پنیر - استرس - مسافرت - دارو های ضد بارداری و ورزش شروع می شود .

· Originates from the embryonal kidney
· Pathologically contains renal tissue with various degrees of differentiation
· Affects about 1 in 10,000 live births
· 60% present before the age of three years
· 10% tumours are bilateral
· The presentation is with an:
Abdominal mass (90%)
Abdominal pain (20%)
Haematuria (30%)

· Diagnosis can be confirmed by CT scan
· 40% have metastatic spread at presentation but do not prevent cure
· Treatment is with nephrectomy and postoperative chemotherapy and radiotherapy
· Stage 1 disease (localised to kidney) has 3-year survival of >80%
· Stage 4 disease (haematogenous spread) has 3-year survival less than 30%
دوزهای بالای استامینوفن موجب نکروز کبدی مرکز لوبولی می شود .
تنباکو مسئول 90 در صد سرطان های ریه است .
