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IBS

What Is Irritable Bowel Syndrome?

Irritable bowel syndrome (IBS), also known as "spastic colon," is a common disorder. While most people experience digestive troubles once in a while, what sets IBS apart is belly pain and diarrhea or constipation that comes back again and again. IBS affects 10% to 15% of people in North America.

Symptoms of IBS

The main symptoms of IBS are abdominal pain accompanied by a change in bowel habits. This can include constipation, diarrhea, or both. Gas and a visibly bloated belly are also common. The condition does not damage the digestive system, but persistent pain and frequent trips to the bathroom can interfere with everyday life.

Causes of IBS

Doctors don't know the exact cause of IBS. One theory is that the signals between the brain and intestines are somehow disrupted. This miscommunication may cause abnormal intestinal muscle contractions (seen on the right) that result in cramping, pain, and fluctuations in the speed of digestion. Patients have no sign of inflamed or damaged tissue or structural abnormalities in the digestive tract.

IBS: Who's at Risk?

Anyone can get IBS, but the condition is twice as common in women as in men. It's also more likely to affect people who have a family history of IBS. Symptoms usually begin when people are in their late 20s. It's uncommon for people over 50 to develop IBS for the first time. IBS sometimes co-exists with depression or anxiety.

Diagnosing IBS

There is no standard test to check for IBS. Doctors usually make a diagnosis based on a patient's description of the symptoms. For this reason, it's important to be candid and specific about the problems you are having. Your doctor may order tests to rule out other causes of your symptoms.

IBS: Impact on Daily Life

IBS may not put your life at risk, but it can take a significant toll on your lifestyle. During episodes of frequent, urgent diarrhea, you may find it difficult to commute to work or travel by air. You may find it necessary to map out bathrooms before going anyplace new. In severe cases, patients may become hesitant to eat out, see a movie, or socialize.

IBS and Stress

Whether you have IBS or not, you're probably familiar with the "butterflies in the stomach" that accompany public speaking, a college final, or other high-stakes events. Stress may trigger or worsen symptoms of IBS. This means that stress can be particularly problematic for people with IBS. IBS symptoms can cause stress, and stress can make the symptoms worse, leading to a vicious cycle.

IBS Triggers

The first step toward managing IBS is to identify what makes your symptoms worse. Besides stress, common triggers include eating a meal, hormonal changes, and certain medications. It's important to note that no specific foods have been universally linked to IBS symptoms. But keeping a food diary may help you pinpoint which foods are a problem for you.

Treating IBS: Diet Changes

Your treatment strategy will depend on your specific symptoms and triggers, but many people start with diet changes. You may find it helpful to avoid caffeine, alcohol, and fatty foods. Getting more fiber or water may also improve symptoms. Suspicious foods can be eliminated one at a time. It may take some trial and error to discover which changes provide the most relief.

Treating IBS: Probiotics

Probiotics are friendly bacteria that help reduce the growth of harmful organisms in the digestive tract. There are many kinds of probiotics, but the best known is the type found in yogurt -- look for a label that says "active cultures." Some studies suggest probiotics may reduce the occurrence of diarrhea, but more research is needed to determine whether this includes symptoms caused by IBS.

Treating IBS: Drugs for Diarrhea

If diet changes do not provide enough relief, your doctor may recommend prescription or over-the-counter medications that target your specific symptoms. For diarrhea, the options include common antidiarrheals (such as Imodium or Lomotil), which slow the motion in the intestines. This type of medicine can also cause constipation, so keeping in close contact with your doctor is important.

Treating IBS: Drugs for Constipation

Occasionally, your doctor may prescribe medication to boost the amount of fluid in the intestines. You can also ask your doctor about over-the-counter laxatives, such as Milk of Magnesia or Miralax, which make the stool softer and easier to pass. Stimulant laxatives such as Correctol and Senokot speed up the motion of stool through the intestines, but should not be used regularly.

Treating IBS: Antidepressants and Antispasmodics

If a doctor prescribes antidepressants for IBS, this does not suggest your symptoms are "all in your head" or caused by depression. Antidepressants act on the chemical messengers in the digestive tract and can ward off pain and cramping. Antispasmodics may also be useful if cramping is a major symptom. Most medications have side effects, so be sure to discuss the pros and cons with your doctor.

Treating IBS: Peppermint Oil

If you prefer a natural remedy, peppermint oil is worth a try. Studies suggest that it may be effective in relieving IBS symptoms. In fact, it performed better than a placebo at relieving symptoms in some people with IBS. Look for enteric-coated capsules, which are less likely to cause heartburn -- and check with your doctor first if you're taking other medications.

Treating IBS: Psychotherapy

Because stress is known to make IBS worse, stress management can be highly beneficial. Cognitive-behavioral therapy is a form of psychotherapy that helps you replace negative thoughts with more positive or realistic ones. This can reduce stress, which in turn, reduces the pain and digestive symptoms associated with IBS. Therapy can also help you learn coping strategies for when your symptoms do flare up.

Treating IBS: Hypnosis

Hypnosis takes patients into an altered state of consciousness, where they receive suggestions for making the pain fade away. Some research indicates hypnosis can reduce pain, digestive symptoms, and anxiety linked to IBS.

Treating IBS: Biofeedback

Biofeedback teaches patients to recognize and change their body's response to stress. After a few sessions, many people are able to slow down their heart rate and enter a more relaxed state. This can be useful in relieving both the stress and symptoms of IBS.

Treating IBS: Relaxation Therapy

Many people can learn to calm themselves through meditation, guided imagery, deep breathing, or other relaxation therapies. Studies suggest these techniques can help with a variety of IBS symptoms, including pain, diarrhea, and constipation. With practice, it's possible to use relaxation techniques just about anywhere.

IBS and Exercise

People with IBS may not feel like exercising, especially when symptoms flare up. But physical activity can help digestion, reduce stress, and induce an overall feeling of well-being. Opt for low-impact activities at first that won't jar the digestive tract, and use the bathroom before you start. Be sure to discuss your plans with your doctor first.

IBS: Long-Term Prognosis

IBS is a chronic condition, and patients may experience quieter periods followed by flare-ups. Keeping a personal diary of food, feelings, and symptoms can help uncover hidden triggers when people are first diagnosed -- and if IBS begins to interfere with daily life again. Over time, the symptoms of IBS typically do not get worse. IBS is not life-threatening and does not lead to more serious conditions, such as inflammatory bowel disease or cancer.


http://www.webmd.com/ibs/ss/slideshow-ibs-overview

Legionnaires disease

Legionnaires disease (LD) was recognized in 1976 after an outbreak of pneumoniaat an American Legion convention in Philadelphia. Soon after, the etiologic agent was identified as a fastidious gram-negative bacillus and named Legionella pneumophila. Although several other species of the genus Legionella were subsequently identified, L pneumophila is the most frequent cause of human legionellosis and a relatively common cause of community-acquired and nosocomial pneumonia in adults. In children, L pneumophila is also an important, although relatively uncommon, cause of pneumonia.

Legionellosis refers to 2 distinct clinical syndromes: Legionnaires disease, which most often manifests as severe pneumonia accompanied by multisystemic disease,and Pontiac fever, which is an acute, febrile, self-limited, viral-like illness.

بیوتروریسم

بیو تروریسم میکروبی به استفاده از پاتوژن های میکروبی به عنوان سلاح هایی که هدف آن ارعاب توده های مردم است اطلاق می شود . کلید مقابله با ان ایجاد یک سیستم آموزش و پایش بهداشت با کارکرد بالاست که حملات را به سرعت شناسایی و به شکل موثری خنثی می کند . عوامل بیوتروریسم طبق دسته بندی مرکز کنترل و پیشگیری از بیماری های ایالات متحده به سه گروه AوBوC تقسیم شده اند و عوامل گروه A پاتوژن های با بالاترین تقدم هستند که بیشترین خطر را برای امنیت ملی ایجاد می کنند . از جمله این عوامل میکروب سیاه زخم (باسیلوس انتراسیس) است که به ندرت از راه تماس بین فردی منتقل می شود . ولی به عنوان یک سلاح زیستی بواسطه رهاسازی هاگ (اسپورها) ی آن مرگ بار است . سه شکل بالینی سیاه زخم وجود دارد :گوارشی و جلدی و استنشاقی .که نوع استنشاقی محتمل ترین علت مرگ در حمله بیوتروریست است . اگر به سرعت تشخیص داده شود درمان آنتی بیوتیکی موفقی دارد . 

Bacillus anthracis is an aerobic spore-forming bacterium that causes disease in humans and animals. The bacteria is found in two forms cutaneous anthrax and inhalation anthrax. Cutaneous anthrax is an infection of the skin caused by direct contact with the bacterium. Inhalation or respiratory anthrax is an infectious disease caused by inhaling the spores of the bacterium. While anthrax commonly affects hoofed animals such as sheep and goats, humans may acquire this disease as well. Anthrax is a potential agent for use as a biological weapon or bio-terrorism.

میگرن

میگرن یک سندرم سردرد خوش خیم و عود کننده همراه با سایر علایم اختلال عملکرد دستگاه عصبی با درصدهای مختلف است . دومین علت شایع سردر ک در 15 درصد زنان و 6 درصد مردان رخ می دهد . 

معیار های تشخیصی :

حداقل دو معیار از موارد زیر :

 1- سردرد یک طرفه  2- سردرد ضربان دار 3-تشدید سردرد با حرکت 4-سردرد متوسط یا شدید 

به علاوه یک از معیار های زیر :

1- تهوع و استفراغ 2- ترس از نور و صدا 

سابقه خانوادگی اغلب مثبت است . سه گانه کلاسیک میگرن عبارتند از : علایم پیش در امد بینایی ، حسی یا حرکتی - سردرد کوبنده یک طرفه - تهوع و استفراغ

یک حمله 4 الی 72 ساعت طول می کشد . حملات گاهی با شراب - پنیر - استرس - مسافرت - دارو های ضد بارداری و ورزش شروع می شود .  

What is a migraine headache?A migraine headache is a form of vascular headache. Migraine headache is caused by vasodilatation (enlargement of blood vessels) that causes the release of chemicals from nerve fibers that coil around the large arteries of the brain. Enlargement of these blood vessels stretches the nerves that coil around them and causes the nerves to release chemicals. The chemicals cause inflammation, pain, and further enlargement of the artery. The increasing enlargement of the arteries .magnifies the pain.Migraine attacks commonly activate the sympathetic nervous system in the body. The sympathetic nervous system is often thought of as the part of the nervous system that controls primitive responses to stress and pain, the so-called "fight or flight" response, and this activation causes many of the symptoms associated with migraine attacks; for example, the increased sympathetic nervous activity in the intestine causes nauseavomiting, anddiarrhea.

(Wilms' tumour)

تومور ویلمز شایع ترین نئوپلاسم کلیوی دوران کودکی است . بیماران مبتلا به سه سندرم : دنیس دراش ، بکویت ویدمن و سندروم تومور ویلمز در معرض خطر بالای ایجاد این تومور اند . بقایای نفروژنی پیش ساز تومورهای ویلمز اند 


·         Originates from the embryonal kidney

·         Pathologically contains renal tissue with various degrees of differentiation

·         Affects about 1 in 10,000 live births

·         60% present before the age of three years

·         10% tumours are bilateral

·         The presentation is with an:

        Abdominal mass (90%)

        Abdominal pain (20%)

        Haematuria (30%)

A young boy with a left nephroblastoma

·         Diagnosis can be confirmed by CT scan

·         40% have metastatic spread at presentation but do not prevent cure

·         Treatment is with nephrectomy and postoperative chemotherapy and radiotherapy

·         Stage 1 disease (localised to kidney) has 3-year survival of >80%

·         Stage 4 disease (haematogenous spread) has 3-year survival less than 30%

دوزهای بالای استامینوفن موجب نکروز کبدی مرکز لوبولی می شود . 

تنباکو مسئول 90 در صد سرطان های ریه است . 

فیبروز کیستیک

فیبروز کیستیک یک بیماری اتوزمومی مغلوب است که به علت جهش در ژن CFTR  در انتقال یون کلرید اختلال ایجاد می کند . این اختلال منجر به غلطت بالای نمک در عرق و ترشحات مجاری تنفسی و گوارشی می شود . جهش ها می توانند شدید باشند و موجب بیماری چند سیستمی گردند . یا خفیف باشند و بیماری با شدت کمتر ایجاد کنند .تظاهرات قلبی شایع ترین علت مرگ است . عفونت های ریوی به خصوص سودوموناهای مقاوم ، شایع اند و برونشکتازی و نارسایی سمت راست قلب در آنها در دراز مدت دیده می شود . نارسایی پانکراس و ناباروری و سیروز در بالغان دیده می شود .

What Is Cystic Fibrosis?