CRTC2

CRTC2
Identifiers
Aliases	CRTC2, TORC-2, TORC2, CREB regulated transcription coactivator 2
External IDs	OMIM: 608972; MGI: 1921593; GeneCards: CRTC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HTM
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,958,615 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,171,432 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left ovary; ; right ovary; ; right hemisphere of cerebellum; ; right lung; ; spleen; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix; ; body of uterus;
	Top expressed in
	neural layer of retina; ; lumbar spinal ganglion; ; tail of embryo; ; genital tubercle; ; granulocyte; ; lip; ; muscle of thigh; ; cerebellar cortex; ; thymus; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	chromatin binding; protein binding; cAMP response element binding protein binding;
Cellular component	cytoplasm; extracellular exosome; nucleus; nucleoplasm;
Biological process	gluconeogenesis; histone H3-K9 acetylation; positive regulation of CREB transcription factor activity; viral process; regulation of transcription, DNA-templated; protein homotetramerization; toxin transport; glucose homeostasis; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	200186
	74343
	ENSG00000160741
	ENSMUSG00000027936
	Q53ET0
	Q3U182
	NM_181715
	NM_028881; NM_001357152
	NP_859066
	NP_083157; NP_001344081
	Wikidata
View/Edit Human	View/Edit Mouse

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.^[5]^[6]^[7]

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.^[8] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).^[9]

Interactions

CRTC2 has been shown to interact with SNF1LK2^[10] and YWHAQ.^[10]^[11]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160741 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027936 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
↑ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX 10.1.1.604.5745. doi:10.1002/bies.20375. PMID 16479585. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
↑ Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7) eaaw6455. Bibcode:2019SciA....5.6455R. doi:10.1126/sciadv.aaw6455. PMC 6656544. PMID 31355336.
1 2 Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160741 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027936 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".

[pmid14506290-6] Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.

[pmid14536081-7] Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.

[pmid16479585-8] Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX 10.1.1.604.5745. doi:10.1002/bies.20375. PMID 16479585. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)

[9] Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7) eaaw6455. Bibcode:2019SciA....5.6455R. doi:10.1126/sciadv.aaw6455. PMC 6656544. PMID 31355336.

[pmid15454081-10] 1 2 Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:

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