NIH Effort Gambles on Mysterious Extracellular RNAs

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³

et al. 2017

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, HSV-1 is well-known for its extensive ability to suppress immunity in cells that it infects (Melchjorsen et al, 2009), so SIDT2-mediated bystander activation – whereby uninfected host cells take up, detect, and respond to extracellular HSV-1 dsRNA released from infected cells – may represent an important counter strategy for host immunity. Along similar lines, recent in vitro experiments have demonstrated a role for dsRNA-based activation of bystander cells in limiting hepatitis C virus (HCV) infection (Dansako et al, 2013), but our results provide evidence that this activation is important in vivo and highlight a physiological role for extracellular RNA at a time when this is a matter of considerable interest and debate (Leslie, 2013). …”

Section: Discussion

supporting

confidence: 71%

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

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²

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³

et al. 2017

Abstract

Proc. Natl. Acad. Sci. U.S.A.

Smart CitationsHow the paper below cites the one you are viewing

“…Although the possibility of exosome-mediated miRNA transfer as a mode of intercellular communication is an attractive concept (6,15,16), current mechanistic models lack detail, and the physiologic significance of this paradigm is not yet established (17). Quantitative evaluation of key components is fundamental to testing the validity of any model (18), and knowledge of the stoichiometry of miRNAs and exosomes (i.e., how many molecules of a given miRNA are carried by an exosome) would provide insight into the requirements and limits of miRNAbased intercellular communication.…”

mentioning

confidence: 99%

Quantitative and stoichiometric analysis of the microRNA content of exosomes

Chevillet

¹

,

Kang²,

Ruf

³

et al. 2014

Abstract

Journal Cellular Physiology

Smart CitationsHow the paper below cites the one you are viewing

“…Although a web-based database contains information on the RNA, protein, and lipid profiles of exosomes, there is a need for continued research into the roles played by exosomes in intercellular communication. Extracellular RNAs can be used as a noninvasive diagnostic tool, and various extracellular RNAs in body fluids, including microRNAs (miRNAs), have been tested for their clinical utility as next-generation biomarkers (Leslie, 2013). Notably, miRNAs are the most abundant long noncoding RNAs (lncRNAs) in exosomes; circulating miRNAs are involved in the development of OC and can be used to predict sensitivity to therapy (Shapira et al, 2014;Xu, Xi, Ge, & Zhang, 2013).…”

mentioning

confidence: 99%

The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches

Yang

¹

,

Kim

²

,

Song

³

et al. 2019

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, HSV-1 is well-known for its extensive ability to suppress immunity in cells that it infects (Melchjorsen et al, 2009), so SIDT2-mediated bystander activation – whereby uninfected host cells take up, detect, and respond to extracellular HSV-1 dsRNA released from infected cells – may represent an important counter strategy for host immunity. Along similar lines, recent in vitro experiments have demonstrated a role for dsRNA-based activation of bystander cells in limiting hepatitis C virus (HCV) infection (Dansako et al, 2013), but our results provide evidence that this activation is important in vivo and highlight a physiological role for extracellular RNA at a time when this is a matter of considerable interest and debate (Leslie, 2013). …”

Section: Discussion

supporting

confidence: 71%

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

¹

,

²

,

³

et al. 2017

Abstract

Proc. Natl. Acad. Sci. U.S.A.

Smart CitationsHow the paper below cites the one you are viewing

“…Although the possibility of exosome-mediated miRNA transfer as a mode of intercellular communication is an attractive concept (6,15,16), current mechanistic models lack detail, and the physiologic significance of this paradigm is not yet established (17). Quantitative evaluation of key components is fundamental to testing the validity of any model (18), and knowledge of the stoichiometry of miRNAs and exosomes (i.e., how many molecules of a given miRNA are carried by an exosome) would provide insight into the requirements and limits of miRNAbased intercellular communication.…”

mentioning

confidence: 99%

Quantitative and stoichiometric analysis of the microRNA content of exosomes

Chevillet

¹

,

Kang²,

Ruf

³

et al. 2014

Abstract

Journal Cellular Physiology

Smart CitationsHow the paper below cites the one you are viewing

“…Although a web-based database contains information on the RNA, protein, and lipid profiles of exosomes, there is a need for continued research into the roles played by exosomes in intercellular communication. Extracellular RNAs can be used as a noninvasive diagnostic tool, and various extracellular RNAs in body fluids, including microRNAs (miRNAs), have been tested for their clinical utility as next-generation biomarkers (Leslie, 2013). Notably, miRNAs are the most abundant long noncoding RNAs (lncRNAs) in exosomes; circulating miRNAs are involved in the development of OC and can be used to predict sensitivity to therapy (Shapira et al, 2014;Xu, Xi, Ge, & Zhang, 2013).…”

mentioning

confidence: 99%

The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches

Yang

¹

,

Kim

²

,

Song

³

et al. 2019

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, HSV-1 is well-known for its extensive ability to suppress immunity in cells that it infects (Melchjorsen et al, 2009), so SIDT2-mediated bystander activation – whereby uninfected host cells take up, detect, and respond to extracellular HSV-1 dsRNA released from infected cells – may represent an important counter strategy for host immunity. Along similar lines, recent in vitro experiments have demonstrated a role for dsRNA-based activation of bystander cells in limiting hepatitis C virus (HCV) infection (Dansako et al, 2013), but our results provide evidence that this activation is important in vivo and highlight a physiological role for extracellular RNA at a time when this is a matter of considerable interest and debate (Leslie, 2013). …”

Section: Discussion

supporting

confidence: 71%

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

¹

,

²

,

³

et al. 2017

Abstract

Proc. Natl. Acad. Sci. U.S.A.

Smart CitationsHow the paper below cites the one you are viewing

“…Although the possibility of exosome-mediated miRNA transfer as a mode of intercellular communication is an attractive concept (6,15,16), current mechanistic models lack detail, and the physiologic significance of this paradigm is not yet established (17). Quantitative evaluation of key components is fundamental to testing the validity of any model (18), and knowledge of the stoichiometry of miRNAs and exosomes (i.e., how many molecules of a given miRNA are carried by an exosome) would provide insight into the requirements and limits of miRNAbased intercellular communication.…”

mentioning

confidence: 99%

Quantitative and stoichiometric analysis of the microRNA content of exosomes

Chevillet

¹

,

Kang²,

Ruf

³

et al. 2014

Abstract

Journal Cellular Physiology

Smart CitationsHow the paper below cites the one you are viewing

“…Although a web-based database contains information on the RNA, protein, and lipid profiles of exosomes, there is a need for continued research into the roles played by exosomes in intercellular communication. Extracellular RNAs can be used as a noninvasive diagnostic tool, and various extracellular RNAs in body fluids, including microRNAs (miRNAs), have been tested for their clinical utility as next-generation biomarkers (Leslie, 2013). Notably, miRNAs are the most abundant long noncoding RNAs (lncRNAs) in exosomes; circulating miRNAs are involved in the development of OC and can be used to predict sensitivity to therapy (Shapira et al, 2014;Xu, Xi, Ge, & Zhang, 2013).…”

mentioning

confidence: 99%

The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches

Yang

¹

,

Kim

²

,

Song

³

et al. 2019

Abstract