Identification and Validation of Quantitative Trait Loci (QTL) for Canine Hip Dysplasia (CHD) in German Shepherd Dogs

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Identification and Validation of Quantitative Trait Loci (QTL) for Canine Hip Dysplasia (CHD) in German Shepherd Dogs

Lena Fels

¹

,

O. Distl

²

Abstract: Canine hip dysplasia (CHD) is the most common hereditary skeletal disorder in dogs. To identify common alleles associated with CHD, we genotyped 96 German Shepherd Dogs affected by mild, moderate and severe CHD and 96 breed, sex, age and birth year matched controls using the Affymetrix canine high density SNP chip. A mixed linear model analysis identified five SNPs associated with CHD scores on dog chromosomes (CFA) 19, 24, 26 and 34. These five SNPs were validated in a by sex, age, birth year and coancestry s… Show more

Cited by 40 publications

(45 citation statements)

References 32 publications

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Smart CitationsHow the paper below cites the one you are viewing

“…However, the exact role of individual PKC isoforms in the regulation of bone function is not fully clear. Our data agree with a recently published study performed with German Shepherd dogs [ 31 ], which has found SNPs associated to CHD located in close proximity to genes which are involved in bone formation and osteoclast activity, underlying the role of bone formation in CHD disease.…”

Section: Discussion

supporting

confidence: 93%

A Genetic Predictive Model for Canine Hip Dysplasia: Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches

¹

,

²

,

³

et al. 2015

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, the exact role of individual PKC isoforms in the regulation of bone function is not fully clear. Our data agree with a recently published study performed with German Shepherd dogs [ 31 ], which has found SNPs associated to CHD located in close proximity to genes which are involved in bone formation and osteoclast activity, underlying the role of bone formation in CHD disease.…”

Section: Discussion

supporting

confidence: 93%

A Genetic Predictive Model for Canine Hip Dysplasia: Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches

¹

,

²

,

³

et al. 2015

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…With ANGPT1 on CFA 13, a gene located in the ROHs shared by above 90% of the PONs was found, which possibly may be involved in the pathogenesis of PDA, because it is known to be involved in angiogenesis [61]. Furthermore, some previously reported loci for CHD were located in homozygous regions in the PONs [46][47][48][49][50][51][52]. It has to be investigated in further studies, if these loci are also relevant in the progression of CHD in PONs.…”

Section: Discussion

mentioning

confidence: 93%

Genetic Variability in Polish Lowland Sheepdogs Assessed by Pedigree and Genomic Data

Michels

¹

,

Distl

²

2020

Animals

Self Cite

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, despite our sample population containing 242 Labrador Retrievers, we did not identify any corresponding regions of significant association. Some of their associated loci [ 8 ] had linkage support from HD mapping in the breeds used in our report [ 9 , 50 – 52 ].…”

Section: Discussion

mentioning

confidence: 94%

A novel iterative mixed model to remap three complex orthopedic traits in dogs

Huang

¹

,

Hayward

²

,

Corey

³

et al. 2017

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, the exact role of individual PKC isoforms in the regulation of bone function is not fully clear. Our data agree with a recently published study performed with German Shepherd dogs [ 31 ], which has found SNPs associated to CHD located in close proximity to genes which are involved in bone formation and osteoclast activity, underlying the role of bone formation in CHD disease.…”

Section: Discussion

supporting

confidence: 93%

A Genetic Predictive Model for Canine Hip Dysplasia: Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches

¹

,

²

,

³

et al. 2015

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…With ANGPT1 on CFA 13, a gene located in the ROHs shared by above 90% of the PONs was found, which possibly may be involved in the pathogenesis of PDA, because it is known to be involved in angiogenesis [61]. Furthermore, some previously reported loci for CHD were located in homozygous regions in the PONs [46][47][48][49][50][51][52]. It has to be investigated in further studies, if these loci are also relevant in the progression of CHD in PONs.…”

Section: Discussion

mentioning

confidence: 93%

Genetic Variability in Polish Lowland Sheepdogs Assessed by Pedigree and Genomic Data

Michels

¹

,

Distl

²

2020

Animals

Self Cite

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, despite our sample population containing 242 Labrador Retrievers, we did not identify any corresponding regions of significant association. Some of their associated loci [ 8 ] had linkage support from HD mapping in the breeds used in our report [ 9 , 50 – 52 ].…”

Section: Discussion

mentioning

confidence: 94%

A novel iterative mixed model to remap three complex orthopedic traits in dogs

Huang

¹

,

Hayward

²

,

Corey

³

et al. 2017

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, the exact role of individual PKC isoforms in the regulation of bone function is not fully clear. Our data agree with a recently published study performed with German Shepherd dogs [ 31 ], which has found SNPs associated to CHD located in close proximity to genes which are involved in bone formation and osteoclast activity, underlying the role of bone formation in CHD disease.…”

Section: Discussion

supporting

confidence: 93%

A Genetic Predictive Model for Canine Hip Dysplasia: Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches

¹

,

²

,

³

et al. 2015

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…With ANGPT1 on CFA 13, a gene located in the ROHs shared by above 90% of the PONs was found, which possibly may be involved in the pathogenesis of PDA, because it is known to be involved in angiogenesis [61]. Furthermore, some previously reported loci for CHD were located in homozygous regions in the PONs [46][47][48][49][50][51][52]. It has to be investigated in further studies, if these loci are also relevant in the progression of CHD in PONs.…”

Section: Discussion

mentioning

confidence: 93%

Genetic Variability in Polish Lowland Sheepdogs Assessed by Pedigree and Genomic Data

Michels

¹

,

Distl

²

2020

Animals

Self Cite

Abstract

Smart CitationsHow the paper below cites the one you are viewing

“…However, despite our sample population containing 242 Labrador Retrievers, we did not identify any corresponding regions of significant association. Some of their associated loci [ 8 ] had linkage support from HD mapping in the breeds used in our report [ 9 , 50 – 52 ].…”

Section: Discussion

mentioning

confidence: 94%

A novel iterative mixed model to remap three complex orthopedic traits in dogs

Huang

¹

,

Hayward

²

,

Corey

³

et al. 2017

Abstract