Abatacept
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| Clinical data | |
|---|---|
| Trade names | Orencia |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a606016 |
| License data | |
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| Routes of administration | Intravenous, subcutaneous |
| ATC code | |
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| Legal status | |
| Pharmacokinetic data | |
| Elimination half-life | 13.1 days |
| Identifiers | |
| CAS Number | |
| DrugBank | |
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| Chemical and physical data | |
| Formula | C3498H5458N922O1090S32 |
| Molar mass | 78,895.43 g·mol−1 |
  (what is this?) (verify) | |
Abatacept, sold under the brand name Orencia, is a drug. It is used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells. It is a modified antibody.
Abatacept is a fusion protein composed of the Fc region of the immunoglobulin IgG1 fused to the extracellular domain of CTLA-4. In order for a T cell to be activated and produce an immune response, an antigen-presenting cell must present two signals to the T cell.[further explanation needed]
References
[change | change source]- ↑ "Orencia- abatacept injection, powder, lyophilized, for solution Orencia- abatacept injection, solution". DailyMed. 15 December 2021. Retrieved 16 March 2022.
- ↑ "FDA approves abatacept for prophylaxis of acute graft". U.S. Food and Drug Administration (FDA). 15 December 2021. Archived from the original on 24 January 2022. Retrieved 16 March 2022.
- ↑ "Orencia EPAR". European Medicines Agency (EMA). 5 June 2007. Retrieved 6 October 2020.
